Ученые создали химеру свиньи и человека

Эмбрионам разрешали развиваться в течение 28 дней

Ученые создали химеру свиньи и человека

Ученые вводили человеческие клетки в эмбрионы свиньи

Человеческие стволовые клетки вживляли в эмбрионы свиньи, в результате чего получалась смесь из человеческих и свиных клеток.

Ученые вырастили первые в мире эмбрионы-химеры, состоящие из клеток человека и свиньи, говорится в исследовании, опубликованном в журнале the Cell.

Доля человеческих клеток в эмбрионе составляет меньше 0,001%, остальное — клетки свиньи. Эмбрионам дали развиваться лишь 28 дней.

Эти эмбрионы могут помочь создать технологию по выращиванию человеческих органов внутри животных.

Ученые вживляли человеческие стволовые клетки в эмбрионы свиньи. В результате получалась смесь из человеческих и свиных клеток, которую на месяц подсаживали самке свиньи.

Этот процесс оказался очень неэффективным: из 2 075 подсаженных эмбрионов в течение 28 дней развивались лишь 186 штук.

Однако при этом были признаки того, что человеческие клетки продолжают функционировать как часть химеры.

«Впервые человеческие клетки росли внутри крупного животного», — объяснил Би-би-си один из авторов исследования профессор Хуан Карлос Исписуа Бельмонте из Института биологических исследований Солка.

Невысокую эффективность примененного метода профессор объяснил долгой эволюцией, которая разделяла человека и свинью. Например, развитие плода свиньи происходит намного быстрее, чем у человека. Беременность свиньи длится четыре месяца против девяти у человека.

Бельмонте сравнил этот процесс с шоссе, где одна машина едет намного быстрее, чем другая, что приводит к столкновениям.

Уже сейчас, по мнению ученых, подобные химеры могут помочь в проверке лекарств до перехода к испытаниям на людях и при изучении начала развития человеческих заболеваний. Также химеры могут помочь изучить ранние стадии развития человеческих эмбрионов и объяснить различия в том, как функционируют органы разных живых существ.

Фактически ученым для этого нужно лишь увеличить долю человеческих клеток в эмбрионе до 0,1-1%.

В Великобритании впервые появилась клонированная собака

Источник: korrespondent.net

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